Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM89116
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay
IC50
70200±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1 yeast via a luminescent assay PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM89116
Synonyms:
7-bromanyl-2-[(5-piperidin-1-ylsulfonylpyridin-2-yl)sulfanylmethyl]pyrido[1,2-a]pyrimidin-4-one | 7-bromo-2-[(5-piperidin-1-ylsulfonylpyridin-2-yl)sulfanylmethyl]pyrido[1,2-a]pyrimidin-4-one | 7-bromo-2-[[(5-piperidinosulfonyl-2-pyridyl)thio]methyl]pyrido[1,2-a]pyrimidin-4-one | 7-bromo-2-[[[5-(1-piperidinylsulfonyl)-2-pyridinyl]thio]methyl]-4-pyrido[1,2-a]pyrimidinone | MLS-0463383.0001 | cid_16314254
Type:
Small organic molecule
Emp. Form.:
C19H19BrN4O3S2
Mol. Mass.:
495.413
SMILES:
Brc1ccc2nc(CSc3ccc(cn3)S(=O)(=O)N3CCCCC3)cc(=O)n2c1
Structure:
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