Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM89104
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
43990±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM89104
Synonyms:
2-[2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxidanylidene-ethyl]sulfanyl-N-[2-(3-methylphenoxy)phenyl]ethanamide | 2-[2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl]sulfanyl-N-[2-(3-methylphenoxy)phenyl]acetamide | 2-[[2-[(5-methyl-3-isoxazolyl)amino]-2-oxoethyl]thio]-N-[2-(3-methylphenoxy)phenyl]acetamide | 2-[[2-keto-2-[(5-methylisoxazol-3-yl)amino]ethyl]thio]-N-[2-(3-methylphenoxy)phenyl]acetamide | MLS-0403852.0001 | cid_25161903
Type:
Small organic molecule
Emp. Form.:
C21H21N3O4S
Mol. Mass.:
411.474
SMILES:
Cc1cc(NC(=O)CSCC(=O)Nc2ccccc2Oc2cccc(C)c2)no1
Structure:
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