Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM77014
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
6260±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2012)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM77014
Synonyms:
MLS000088012 | N-(1,3-benzothiazol-2-yl)-1-(4-chlorophenyl)sulfonyl-2-pyrrolidinecarboxamide | N-(1,3-benzothiazol-2-yl)-1-(4-chlorophenyl)sulfonyl-pyrrolidine-2-carboxamide | N-(1,3-benzothiazol-2-yl)-1-(4-chlorophenyl)sulfonylpyrrolidine-2-carboxamide | N-1,3-benzothiazol-2-yl-1-[(4-chlorophenyl)sulfonyl]prolinamide | SMR000072212 | cid_2936947
Type:
Small organic molecule
Emp. Form.:
C18H16ClN3O3S2
Mol. Mass.:
421.921
SMILES:
Clc1ccc(cc1)S(=O)(=O)N1CCCC1C(=O)Nc1nc2ccccc2s1
Structure:
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