Reaction Details Report a problem with these data
Target
Zinc finger protein GLI1
Ligand
BDBM89280
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay
IC50
2790±n/a nM
Citation
 PubChem, PC Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Zinc finger protein GLI1
Synonyms:
GLI1_MOUSE | Gli | Gli1 | Glioma-associated oncogene homolog
Type:
PROTEIN
Mol. Mass.:
118579.34
Organism:
Mus musculus
Description:
EBI_101259
Residue:
1111
Sequence:
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
  
Inhibitor
Name:
BDBM89280
Synonyms:
1-(3,4-Dichloro-benzyl)-3-p-tolyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium | 1-(3,4-dichlorobenzyl)-3-(p-tolyl)-6,7-dihydro-5H-pyrrol[1,2-a]imidazol-1-ium;chloride | 1-[(3,4-dichlorophenyl)methyl]-3-(4-methylphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-1-ium;chloride | MLS000580334 | SMR000220552 | cid_12005697
Type:
Small organic molecule
Emp. Form.:
C20H19Cl2N2
Mol. Mass.:
358.284
SMILES:
Cc1ccc(cc1)-c1c[n+](Cc2ccc(Cl)c(Cl)c2)c2CCCn12
Structure:
Search PDB for entries with ligand similarity: