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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM278785
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
pH
7.2±n/a
IC50
188±n/a nM
Comments
extracted
Citation
 Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolopyridazine inhibitors of IRAK4 activity US Patent  US10040798 Publication Date 8/7/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM278785
Synonyms:
N-(4-chlorothiophen-3- yl)-2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct- 2-yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate | US10040798, Example 83
Type:
Small organic molecule
Emp. Form.:
C20H19ClF3N5O3S
Mol. Mass.:
501.91
SMILES:
OC(=O)C(F)(F)F.Clc1cscc1NC(=O)c1ccc2ccc(nn12)N1C[C@@H]2CC[C@H]1CN2 |r|
Structure:
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