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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM278803
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
pH
7.2±n/a
IC50
766±n/a nM
Comments
extracted
Citation
 Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolopyridazine inhibitors of IRAK4 activity US Patent  US10040798 Publication Date 8/7/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM278803
Synonyms:
N-(2- cyanophenyl)-2- (5,8- diazaspiro[2.6]non- 5-yl)pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate | US10040798, Example 103
Type:
Small organic molecule
Emp. Form.:
C24H23F3N6O3
Mol. Mass.:
500.473
SMILES:
OC(=O)C(F)(F)F.O=C(Nc1ccccc1C#N)c1ccc2ccc(nn12)N1CCNCC2(CC2)C1
Structure:
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