Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM278807
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
pH
7.2±n/a
IC50
26.0±n/a nM
Comments
extracted
Citation
 Lim, JAltman, MDBrubaker, JDGibeau, CR Pyrrolopyridazine inhibitors of IRAK4 activity US Patent  US10040798 Publication Date 8/7/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM278807
Synonyms:
2-[(3R)-3- aminopiperidin-1- yl]-N-(2-cyanophenyl) pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate | US10040798, Example 107
Type:
Small organic molecule
Emp. Form.:
C22H21F3N6O3
Mol. Mass.:
474.4357
SMILES:
OC(=O)C(F)(F)F.N[C@@H]1CCCN(C1)c1ccc2ccc(C(=O)Nc3ccccc3C#N)n2n1 |r|
Structure:
Search PDB for entries with ligand similarity: