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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89603
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89603
Synonyms:
(3,5-dimethyl-1,2-oxazol-4-yl)methyl 2,5-dimethyl-1-phenyl-pyrrole-3-carboxylate | (3,5-dimethyl-1,2-oxazol-4-yl)methyl 2,5-dimethyl-1-phenylpyrrole-3-carboxylate | 2,5-dimethyl-1-phenyl-3-pyrrolecarboxylic acid (3,5-dimethyl-4-isoxazolyl)methyl ester | 2,5-dimethyl-1-phenyl-pyrrole-3-carboxylic acid (3,5-dimethylisoxazol-4-yl)methyl ester | MLS000098702 | SMR000063746 | cid_2124287
Type:
Small organic molecule
Emp. Form.:
C19H20N2O3
Mol. Mass.:
324.3737
SMILES:
Cc1cc(C(=O)OCc2c(C)noc2C)c(C)n1-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: