Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89630
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89630
Synonyms:
5-[[[3-(3-methoxyphenyl)-4-oxo-2-quinazolinyl]thio]methyl]-2-furancarboxylic acid methyl ester | 5-[[[4-keto-3-(3-methoxyphenyl)quinazolin-2-yl]thio]methyl]furan-2-carboxylic acid methyl ester | MLS000098475 | SMR000065105 | cid_2595628 | methyl 5-[[3-(3-methoxyphenyl)-4-oxidanylidene-quinazolin-2-yl]sulfanylmethyl]furan-2-carboxylate | methyl 5-[[3-(3-methoxyphenyl)-4-oxoquinazolin-2-yl]sulfanylmethyl]furan-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H18N2O5S
Mol. Mass.:
422.454
SMILES:
COC(=O)c1ccc(CSc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)o1
Structure:
Search PDB for entries with ligand similarity: