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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM42716
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM42716
Synonyms:
2-[[3-(1-ethyl-3-methyl-pyrazol-4-yl)-2-isoxazoline-5-carbonyl]amino]benzoic acid methyl ester | 2-[[[3-(1-ethyl-3-methyl-4-pyrazolyl)-4,5-dihydroisoxazol-5-yl]-oxomethyl]amino]benzoic acid methyl ester | MLS000093180 | SMR000028808 | cid_3240660 | methyl 2-({[3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydroisoxazol-5-yl]carbonyl}amino)benzoate | methyl 2-[[3-(1-ethyl-3-methyl-pyrazol-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]carbonylamino]benzoate | methyl 2-[[3-(1-ethyl-3-methylpyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carbonyl]amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C18H20N4O4
Mol. Mass.:
356.3758
SMILES:
CCn1cc(C2=NOC(C2)C(=O)Nc2ccccc2C(=O)OC)c(C)n1 |t:5|
Structure:
Search PDB for entries with ligand similarity: