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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89954
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
2780±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89954
Synonyms:
2,4-bis(chloranyl)-N-[[(4-methylphenyl)carbonylamino]carbamothioyl]benzamide | 2,4-dichloro-N-[(p-toluoylamino)thiocarbamoyl]benzamide | 2,4-dichloro-N-[[(4-methylbenzoyl)amino]carbamothioyl]benzamide | 2,4-dichloro-N-[[[(4-methylphenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]benzamide | 2,4-dichloro-N-{[2-(4-methylbenzoyl)hydrazino]carbothioyl}benzamide | MLS000325022 | SMR000160631 | cid_1790620
Type:
Small organic molecule
Emp. Form.:
C16H13Cl2N3O2S
Mol. Mass.:
382.264
SMILES:
Cc1ccc(cc1)C(=O)NNC(=S)NC(=O)c1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: