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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM75808
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
460±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM75808
Synonyms:
(2E)-5-bromo-4-chloro-2-{[(3-methylphenyl)amino]methylene}-1,2-dihydro-3H-indol-3-one | (2Z)-5-bromanyl-4-chloranyl-2-[[(3-methylphenyl)amino]methylidene]-1H-indol-3-one | (2Z)-5-bromo-4-chloro-2-(m-toluidinomethylene)pseudoindoxyl | (2Z)-5-bromo-4-chloro-2-[(3-methylanilino)methylidene]-1H-indol-3-one | MLS000586006 | SMR000207785 | cid_15945110
Type:
Small organic molecule
Emp. Form.:
C16H12BrClN2O
Mol. Mass.:
363.636
SMILES:
Cc1cccc(c1)N=Cc1[nH]c2ccc(Br)c(Cl)c2c1O |w:7.7|
Structure:
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