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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM91461
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
3200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM91461
Synonyms:
5-[4-(dimethylamino)benzylidene]-3-(2-furfuryl)-2-thioxo-thiazolidin-4-one | 5-[[4-(dimethylamino)phenyl]methylidene]-3-(2-furanylmethyl)-2-sulfanylidene-4-thiazolidinone | 5-[[4-(dimethylamino)phenyl]methylidene]-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one | MLS003115998 | SMR001831556 | US20230364057, Compound 228 | cid_330810
Type:
Small organic molecule
Emp. Form.:
C17H16N2O2S2
Mol. Mass.:
344.451
SMILES:
CN(C)c1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1
Structure:
Search PDB for entries with ligand similarity: