Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM278915
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
pH
7.2±n/a
IC50
0.500±n/a nM
Comments
extracted
Citation
 Lim, JAltman, MDGibeau, CR Thienopyrazine inhibitors of IRAK4 activity US Patent  US10040802 Publication Date 8/7/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM278915
Synonyms:
2-{[(1R,2S)-2- aminocyclohexyl]- amino}-N-(2- cyanophenyl)- thieno[2,3-b]- pyrazine-7- carboxamide trifluoroacetate | US10040802, Example 95
Type:
Small organic molecule
Emp. Form.:
C22H21F3N6O3S
Mol. Mass.:
506.501
SMILES:
OC(=O)C(F)(F)F.N[C@H]1CCCC[C@H]1Nc1cnc2scc(C(=O)Nc3ccccc3C#N)c2n1 |r|
Structure:
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