Reaction Details Report a problem with these data
Target
dCTP deaminase
Ligand
BDBM50173540
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
Ki
1.000000e+9±n/a nM
Citation
 Musso-Buendía, JA; Vidal, AE; Kasinthan, G; Nguyen, C; Carrero-Lérida, J; Ruiz-Pérez, LM; Wilson, K; Johansson, NG; Gilbert, IH; González-Pacanowska, D Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. J Enzyme Inhib Med Chem 24:111-6 (2009) [PubMed]  Article 
Target
Name:
dCTP deaminase
Synonyms:
DCD_CAMJE | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | dcd
Type:
Protein
Mol. Mass.:
20698.65
Organism:
Campylobacter jejuni
Description:
n/a
Residue:
186
Sequence:
MGLKADNWIRKMALEHKMIEPFCEANIGKGVVSYGLSSYGYDIRVGREFKIFTNVNSTVVDPKNFVEENVVDFEGDVCIVPANSFALARTIEYFKMPDNVLAICLGKSTYARCGIIVNVTPFEPGFEGHITIEISNTTPLPAKIYANEGIAQVLFLQGDEKCDTTYKDKKGKYQAQTGITLPRILK
  
Inhibitor
Name:
BDBM50173540
Synonyms:
1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione | CHEMBL371690 | dUTPase inhibitor, 5
Type:
Small organic molecule
Emp. Form.:
C25H28N2O4Si
Mol. Mass.:
448.5863
SMILES:
CC(C)(C)[Si](OCC1OC(C=C1)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1 |c:10|
Structure:
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