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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM92329
Substrate
n/a
Meas. Tech.
5Alpha-Reductase Activity Assay
pH
6.5±0
Temperature
310.15±0 K
IC50
13±0.0 nM
Citation
 Bratoeff, E; Segura, T; Recillas, S; Carrizales, E; Palacios, A; Heuze, I; Cabeza, M Aromatic esters of progesterone as 5alpha-reductase and prostate growth inhibitors. J Enzyme Inhib Med Chem 24:655-62 (2009) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM92329
Synonyms:
Steroid, 10a
Type:
Small organic molecule
Emp. Form.:
C28H34O5
Mol. Mass.:
450.5666
SMILES:
CC(=O)[C@]1(CCC2C3CC[C@@]45O[C@@H]4C(=O)CC[C@]5(C)C3CC[C@]12C)OC(=O)c1ccccc1
Structure:
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