Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM92336
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6±0
Temperature
310.15±0 K
Ki
9.0e+2± 2e+1 nM
Citation
 Löser, R; Gütschow, M Dipeptide-derived nitriles containing additional electrophilic sites: potentially irreversible inhibitors of cysteine proteases. J Enzyme Inhib Med Chem 24:1245-52 (2009) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_BOVIN | CTSL | CTSL1 | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain
Type:
Enzyme
Mol. Mass.:
37349.52
Organism:
Bos taurus (bovine)
Description:
Bovine liver cathepsin L was purchased from Calbiochem.
Residue:
334
Sequence:
MNPSFFLTVLCLGVASAAPKLDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHGFRMAMNAFGDMTNEEFRQVMNGFQNQKHKKGKLFHEPLLVDVPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV
  
Inhibitor
Name:
BDBM92336
Synonyms:
Dipeptide nitrile, 10
Type:
Small organic molecule
Emp. Form.:
C18H22N4O3
Mol. Mass.:
342.3923
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC#N)C#N |r|
Structure:
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