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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM223004
Substrate
n/a
Meas. Tech.
Human Indoleamine 2,3-Dioxygenasae (IDO) Enzyme Assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
<200±n/a nM
Comments
extracted
Citation
 Combs, AP; Yue, EW; Sparks, RB; Zhu, W 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase US Patent  US10034864 Publication Date 7/31/2018 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM223004
Synonyms:
US10034939, Example 6 | US10967060, Example 6 | US11207302, Example 6 | US9320732, 6
Type:
Small organic molecule
Emp. Form.:
C12H14ClFN6O4S
Mol. Mass.:
392.794
SMILES:
CS(=O)(=O)NCCNc1nonc1C(Nc1ccc(F)c(Cl)c1)=NO |w:23.25|
Structure:
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