Reaction Details Report a problem with these data
Target
Bifunctional ligase/repressor BirA
Ligand
BDBM92382
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
Ki
1.17e+3± 1.7e+2 nM
Citation
 Soares da Costa, TP; Tieu, W; Yap, MY; Pendini, NR; Polyak, SW; Sejer Pedersen, D; Morona, R; Turnidge, JD; Wallace, JC; Wilce, MC; Booker, GW; Abell, AD Selective inhibition of biotin protein ligase from Staphylococcus aureus. J Biol Chem 287:17823-32 (2012) [PubMed]  Article 
Target
Name:
Bifunctional ligase/repressor BirA
Synonyms:
Biotin ligase | Biotin protein ligase (BPL)
Type:
Protein
Mol. Mass.:
37140.09
Organism:
Staphylococcus aureus
Description:
W8TTE7
Residue:
323
Sequence:
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLDRYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISADIDF
  
Inhibitor
Name:
BDBM92382
Synonyms:
Biotin triazole, 13
Type:
Small organic molecule
Emp. Form.:
C26H33N5O2S
Mol. Mass.:
479.638
SMILES:
O=C1NC2CS[C@@H](CCCCCc3cn(CCCCOc4ccc5ccccc5c4)nn3)C2N1 |r|
Structure:
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