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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM223017
Substrate
n/a
Meas. Tech.
Human indoleamine 2,3-dioxygenasae (IDO) enzyme assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
<500±n/a nM
Comments
extracted
Citation
 Gajewski, TF; Spranger, S; Leung, M Synergistic combination of immunologic inhibitors for the treatment of cancer US Patent  US10034939 Publication Date 7/31/2018 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM223017
Synonyms:
US10034939, Example 19 | US10967060, Example 19 | US11207302, Example 19 | US9320732, 19 | US9789094, 19
Type:
Small organic molecule
Emp. Form.:
C13H14FN7O4S
Mol. Mass.:
383.358
SMILES:
CS(=O)(=O)NCCNc1nonc1C(Nc1ccc(F)c(c1)C#N)=NO |w:24.26|
Structure:
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