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Target
Phosphoethanolamine N-methyltransferase 2
Ligand
BDBM92471
Substrate
n/a
Meas. Tech.
Radiochemical Assay
pH
8±0
Temperature
298.15±0 K
IC50
9.15e+4± 4.6e+3 nM
Citation
 Lee, SG; Haakenson, W; McCarter, JP; Williams, DJ; Hresko, MC; Jez, JM Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. J Biol Chem 286:38060-8 (2011) [PubMed]  Article 
Target
Name:
Phosphoethanolamine N-methyltransferase 2
Synonyms:
Phosphoehtnaolamine Methyltransferases 2 (PMT2)
Type:
Enzyme
Mol. Mass.:
49764.45
Organism:
Caenorhabditis elegans
Description:
Q22993
Residue:
437
Sequence:
MSSLSIPRQSLYYVNKVTEGRSVSNVQVVSPCQKQGQTYVTAFTPLTSNVQVHTSLEQLSTIRNADVLIFNNALSQIITNADLLTDFLKNATNATAIGGTVIIREDLKDCSDKRQVARLTDYFDVFRTTDSDGNNTGLDLYTVDQVEHSNYVEQNFLDFIFVFRKKVFAPTTDATITFRDFLDKTQYTNTGIDAYEWMFGVNFISPGGYDENLKIIKRFGDFKPGQTMLDIGVGIGGGARQVADEFGVHVHGIDLSSNMLAIALERLHEEKDSRVKYSITDALVYQFEDNSFDYVFSRDCIQHIPDTEKLFSRIYKALKPGGKVLITMYGKGYGEQSDKFKTYVAQRAYFLKNLKEIADIANKTGFVNVQTENMTPRFKEILLEERGHLEQNEAEFMSKFTQRERDSLISGWTDKLGYIEKDNHNWNFFLAQKPFPK
  
Inhibitor
Name:
BDBM92471
Synonyms:
Sinefungin
Type:
Small organic molecule
Emp. Form.:
C15H23N7O5
Mol. Mass.:
381.387
SMILES:
NC(CCC(N)C(O)=O)CC1OC(C(O)C1O)n1cnc2c(N)ncnc12
Structure:
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