Reaction Details Report a problem with these data
Target
Acid phosphatase
Ligand
BDBM50090256
Substrate
n/a
Meas. Tech.
Inhibitor Screening Assay
Ki
3.80e+5± 1.60e+5 nM
Citation
 McRae, S; Pagliai, FA; Mohapatra, NP; Gener, A; Mahmou, AS; Gunn, JS; Lorca, GL; Gonzalez, CF Inhibition of AcpA phosphatase activity with ascorbate attenuates Francisella tularensis intramacrophage survival. J Biol Chem 285:5171-7 (2010) [PubMed]  Article 
Target
Name:
Acid phosphatase
Synonyms:
Acid phosphatase (acpA) | Acid phosphatase (acpB) | Acid phosphatase (acpC)
Type:
Enzyme
Mol. Mass.:
22350.38
Organism:
Francisella tularensis
Description:
Q5NIC0
Residue:
194
Sequence:
MTQQQVISYYESTAHENEVELILARAKKIIQAQQSLQGNAIVLDIDETALNHYYSLKLAGFPQGENHTIWNELLSRTDAYPIKATLDFYLYCLTSGLKVFFISARFAQYLESTKQALRNAGYVNFEDVFVFPENIEQYNSKDFKNFKAERRAYIESLGYKILISIGDQSSDLLGGYTLYTLQLPNYLYGENSRF
  
Inhibitor
Name:
BDBM50090256
Synonyms:
(R)-2-((S)-1,2-dihydroxyethyl)-4,5-dihydroxyfuran-3(2H)-one | (R)-5-((S)-1,2-Dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one | (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one | 5-(1,2-Dihydroxy-ethyl)-3,4-dihydroxy-5H-furan-2-one(AsA) | CHEMBL196 | ascorbic acid | vitamin C
Type:
Small organic molecule
Emp. Form.:
C6H8O6
Mol. Mass.:
176.1241
SMILES:
OC[C@H](O)c1oc(O)c(O)c1O |r|
Structure:
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