Reaction Details Report a problem with these data
Target
Acid phosphatase
Ligand
BDBM92477
Substrate
n/a
Meas. Tech.
Inhibitor Screening Assay
Ki
3.2e+2± 1.6e+2 nM
Citation
 McRae, S; Pagliai, FA; Mohapatra, NP; Gener, A; Mahmou, AS; Gunn, JS; Lorca, GL; Gonzalez, CF Inhibition of AcpA phosphatase activity with ascorbate attenuates Francisella tularensis intramacrophage survival. J Biol Chem 285:5171-7 (2010) [PubMed]  Article 
Target
Name:
Acid phosphatase
Synonyms:
Acid phosphatase (acpA) | Acid phosphatase (acpB) | Acid phosphatase (acpC)
Type:
Enzyme
Mol. Mass.:
22350.38
Organism:
Francisella tularensis
Description:
Q5NIC0
Residue:
194
Sequence:
MTQQQVISYYESTAHENEVELILARAKKIIQAQQSLQGNAIVLDIDETALNHYYSLKLAGFPQGENHTIWNELLSRTDAYPIKATLDFYLYCLTSGLKVFFISARFAQYLESTKQALRNAGYVNFEDVFVFPENIEQYNSKDFKNFKAERRAYIESLGYKILISIGDQSSDLLGGYTLYTLQLPNYLYGENSRF
  
Inhibitor
Name:
BDBM92477
Synonyms:
2-phospho-L-ascorbic acid
Type:
Small molecule
Emp. Form.:
C6H6O9P
Mol. Mass.:
253.0818
SMILES:
OCC(O)c1oc(=O)[c-](OP([O-])([O-])=O)c1O
Structure:
Search PDB for entries with ligand similarity: