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Target
Glutamine-dependent NAD(+) synthetase
Ligand
BDBM92599
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8.5±0
Temperature
310.15±0 K
IC50
2.18e+4± 1.4e+3 nM
Citation
 Boshoff, HI; Xu, X; Tahlan, K; Dowd, CS; Pethe, K; Camacho, LR; Park, TH; Yun, CS; Schnappinger, D; Ehrt, S; Williams, KJ; Barry, CE Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem 283:19329-41 (2008) [PubMed]  Article 
Target
Name:
Glutamine-dependent NAD(+) synthetase
Synonyms:
NAD synthetase | NADE_HUMAN | NADSYN1
Type:
Enzyme
Mol. Mass.:
79282.89
Organism:
Homo sapiens (Human)
Description:
Q6IA69
Residue:
706
Sequence:
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
  
Inhibitor
Name:
BDBM92599
Synonyms:
CHEMBL263057 | NAD Synthetase Inhibitor, 4
Type:
Organic molecule
Emp. Form.:
C35H43N2O5
Mol. Mass.:
571.7258
SMILES:
COC(=O)c1cc2cc(OCc3ccccc3)ccc2n1CCCCCCCOC(=O)Cc1ccc(cc1)[N+](C)(C)C
Structure:
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