Target
Glutamine-dependent NAD(+) synthetase
Ligand
BDBM92600
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8.5±0
Temperature
310.15±0 K
IC50
5.78e+4± 2.2e+3 nM
Citation
 Boshoff, HIXu, XTahlan, KDowd, CSPethe, KCamacho, LRPark, THYun, CSSchnappinger, DEhrt, SWilliams, KJBarry, CE Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli. J Biol Chem 283:19329-41 (2008) [PubMed]  Article 
Target
Name:
Glutamine-dependent NAD(+) synthetase
Synonyms:
NAD synthetase | NADE_HUMAN | NADSYN1
Type:
Enzyme
Mol. Mass.:
79282.89
Organism:
Homo sapiens (Human)
Description:
Q6IA69
Residue:
706
Sequence:
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
  
Inhibitor
Name:
BDBM92600
Synonyms:
CHEMBL419944 | NAD Synthetase Inhibitor, 5
Type:
Organic molecule
Emp. Form.:
C30H41N2O4
Mol. Mass.:
493.657
SMILES:
COC(=O)c1cc2ccccc2n1CCCCCCCCCOC(=O)Cc1ccc(cc1)[N+](C)(C)C
Structure:
Search PDB for entries with ligand similarity: