Reaction Details Report a problem with these data
Target
Phosphatidylcholine-sterol acyltransferase
Ligand
BDBM92615
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.5±0
Temperature
277.15±0 K
IC50
28±0.0 nM
Citation
 Jauhiainen, M; Yuan, w; Gelb, MH; Dolphin, J Human Plasma Lecithin-Cholesterol Acyltransferase J Biol Chem 264:1963-1967 (1989)   
Target
Name:
Phosphatidylcholine-sterol acyltransferase
Synonyms:
LCAT | LCAT_HUMAN | Lecithin-cholesterol acyltransferase (LCAT) | Phosphatidylcholine-sterol acyltransferase | Phospholipid-cholesterol acyltransferase
Type:
Protein
Mol. Mass.:
49573.79
Organism:
Homo sapiens (Human)
Description:
P04180
Residue:
440
Sequence:
MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE
  
Inhibitor
Name:
BDBM92615
Synonyms:
Difluoroketone phospholipid analogue, 3
Type:
n/a
Emp. Form.:
C34H68F2NO6P
Mol. Mass.:
655.8774
SMILES:
CCCCCCCCCCCCCCCCC(=O)C(F)(F)C(COCCCCCCCC)COP([O-])(=O)OCC[N+](C)(C)C
Structure:
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