Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM92939
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
11.4±2 nM
Citation
 Genis, C; Sippel, KH; Case, N; Cao, W; Avvaru, BS; Tartaglia, LJ; Govindasamy, L; Tu, C; Agbandje-McKenna, M; Silverman, DN; Rosser, CJ; McKenna, R Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties. Biochemistry 48:1322-31 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM92939
Synonyms:
Methazolamide, MZM
Type:
Small molecule
Emp. Form.:
C6H9N3O3S2
Mol. Mass.:
235.284
SMILES:
CC1N=C(S\C1=N\C(C)=O)S(N)(=O)=O |c:2|
Structure:
Search PDB for entries with ligand similarity: