Reaction Details Report a problem with these data
Target
DNA gyrase subunit A
Ligand
BDBM50107009
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
3.0e+4±n/a nM
Citation
 Karkare, S; Chung, TT; Collin, F; Mitchenall, LA; McKay, AR; Greive, SJ; Meyer, JJ; Lall, N; Maxwell, A The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem 288:5149-56 (2013) [PubMed]  Article 
Target
Name:
DNA gyrase subunit A
Synonyms:
GYRA_MYCTU | Type IIA topoisomerase subunit GyrA | gyrA
Type:
Protein
Mol. Mass.:
92261.11
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WG47
Residue:
838
Sequence:
MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
  
Inhibitor
Name:
BDBM50107009
Synonyms:
5-Hydroxy-7-methyl-[1,4]naphthoquinone | 5-hydroxy-7-methyl-1,4-naphthoquinone | 7-methyljuglone | CHEMBL430853
Type:
Small organic molecule
Emp. Form.:
C11H8O3
Mol. Mass.:
188.1794
SMILES:
Cc1cc(O)c2C(=O)C=CC(=O)c2c1 |c:8|
Structure:
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