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TargetDNA gyrase
LigandBDBM50107009
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50 3.0e+4± 0 nM
Citation Karkare, SChung, TTCollin, FMitchenall, LAMcKay, ARGreive, SJMeyer, JJLall, NMaxwell, A The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem288:5149-56 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA gyrase
Name:DNA gyrase
Synonyms:n/a
Type:Protein
Mol. Mass.:92247.08
Organism:Mycobacterium tuberculosis
Description:Q07702
Residue:838
Sequence:
MTDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMF
DSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPG
NDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGG
IAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGT
ADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGIS
NIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQ
LIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAG
LIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVR
DELAEIVDRHGDDRRTRIIAADGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRG
GKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLL
AFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELV
GAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLVSLNVVREG
TYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSG
GGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50107009
NameBDBM50107009
Synonyms:5-Hydroxy-7-methyl-[1,4]naphthoquinone | 5-hydroxy-7-methyl-1,4-naphthoquinone | 7-methyljuglone | CHEMBL430853
TypeSmall organic molecule
Emp. Form.C11H8O3
Mol. Mass.188.1794
SMILESCc1cc(O)c2C(=O)C=CC(=O)c2c1 |c:8|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a