Reaction Details Report a problem with these data
Target
Glucose-1-phosphate thymidylyltransferase
Ligand
BDBM93089
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
4.7e+3± 4.0e+3 nM
Citation
 Alphey, MS; Pirrie, L; Torrie, LS; Boulkeroua, WA; Gardiner, M; Sarkar, A; Maringer, M; Oehlmann, W; Brenk, R; Scherman, MS; McNeil, M; Rejzek, M; Field, RA; Singh, M; Gray, D; Westwood, NJ; Naismith, JH Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. ACS Chem Biol 8:387-96 (2013) [PubMed]  Article 
Target
Name:
Glucose-1-phosphate thymidylyltransferase
Synonyms:
Glucose-1-phosphate thymidylyltransferase (RmlA)
Type:
Protein
Mol. Mass.:
32451.00
Organism:
Pseudomonas aeruginosa
Description:
Q9HU22
Residue:
293
Sequence:
MKRKGIILAGGSGTRLHPATLAISKQLLPVYDKPMIYYPLSTLMLAGIREILIISTPQDTPRFQQLLGDGSNWGLDLQYAVQPSPDGLAQAFLIGESFIGNDLSALVLGDNLYYGHDFHELLGSASQRQTGASVFAYHVLDPERYGVVEFDQGGKAISLEEKPLEPKSNYAVTGLYFYDQQVVDIARDLKPSPRGELEITDVNRAYLERGQLSVEIMGRGYAWLDTGTHDSLLEAGQFIATLENRQGLKVACPEEIAYRQKWIDAAQLEKLAAPLAKNGYGQYLKRLLTETVY
  
Inhibitor
Name:
BDBM93089
Synonyms:
Analogue of 1a, 12b
Type:
Small molecule
Emp. Form.:
C13H16N4O2
Mol. Mass.:
260.2917
SMILES:
CCNc1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
Structure:
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