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Target
Beta-1 adrenergic receptor
Ligand
BDBM93102
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
38500±12600 nM
Citation
 Kossakowski, J; Bielenica, A; Struga, M; Koziol, A Synthesis and pharmacological evaluation of 4-[2- hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4- azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Medicinal Chemistry Research 17:507-514 (2008)    Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1R, B1AR | ADRB1_RAT | Adrb1 | Adrb1r | Adrenergic receptor beta | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 | adrenergic Beta1,2
Type:
Protein
Mol. Mass.:
50486.84
Organism:
Rattus norvegicus (Rat)
Description:
P18090
Residue:
466
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
  
Inhibitor
Name:
BDBM93102
Synonyms:
4-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propoxy]-4-azatricyclo[5.2.1.0^{2,6}]dec-8-ene-3,5-dione, 3
Type:
Small molecule
Emp. Form.:
C22H27N3O4
Mol. Mass.:
397.4675
SMILES:
OC(CON1C(=O)C2C3CC(C=C3)C2C1=O)CN1CCN(CC1)c1ccccc1 |c:11|
Structure:
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