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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM93114
Substrate
BDBM24514
Meas. Tech.
In Vitro Assay
pH
7±0
Ki
1.70e+5±n/a nM
IC50
4.85e+5±n/a nM
Citation
 Maurya, R; Gupta, P; Ahmad, G; Yadav, DK; Chand, K; Singh, AB; Tamrakar, AK; Srivastava, AK Synthesis of 3,5-disubstituted isoxazolines as protein tyrosine phosphatase 1B inhibitors Medicinal Chemistry Research 17:123-136 (2008)    Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM93114
Synonyms:
PTP1B Inhibitor, 12
Type:
Small molecule
Emp. Form.:
C16H14N2O3
Mol. Mass.:
282.294
SMILES:
COc1cc(C=O)ccc1C1=NOC(C1)c1ccccn1 |t:11|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM24514
Synonyms:
4-nitrophenoxyphosphonic acid | 4-nitrophenyl phosphate | CHEMBL24231 | p-nitrophenyl phosphate
Type:
Small organic molecule
Emp. Form.:
C6H6NO6P
Mol. Mass.:
219.0887
SMILES:
OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: