Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM93117
Substrate
BDBM24514
Meas. Tech.
In Vitro Assay
pH
7±0
Ki
1.35e+5±n/a nM
IC50
1.65e+5±n/a nM
Citation
 Maurya, RGupta, PAhmad, GYadav, DKChand, KSingh, ABTamrakar, AKSrivastava, AK Synthesis of 3,5-disubstituted isoxazolines as protein tyrosine phosphatase 1B inhibitors Medicinal Chemistry Research 17:123-136 (2008)    Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM93117
Synonyms:
PTP1B Inhibitor, 15
Type:
Small molecule
Emp. Form.:
C19H17NO5
Mol. Mass.:
339.342
SMILES:
COC(=O)C1C(ON=C1c1ccc(C=O)cc1OC)c1ccccc1 |c:7|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM24514
Synonyms:
4-nitrophenoxyphosphonic acid | 4-nitrophenyl phosphate | CHEMBL24231 | p-nitrophenyl phosphate
Type:
Small organic molecule
Emp. Form.:
C6H6NO6P
Mol. Mass.:
219.0887
SMILES:
OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: