Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM93173
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±0
Ki
>1000±0.0 nM
Citation
 Yamashita, DS; Dong, X; Oh, HJ; Brook, CS; Tomaszek, TA; Szewczuk, L; Tew, DG; Veber, DF Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L. J Comb Chem 1:207-15 (1999) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM93173
Synonyms:
Cathepsin Inhibitor, Column 2 Row 3
Type:
Small molecule
Emp. Form.:
C30H31F3N4O4
Mol. Mass.:
568.5867
SMILES:
CC(C)[C@H](NC(=O)c1ccc(cc1)C(F)(F)F)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1 |r|
Structure:
Search PDB for entries with ligand similarity: