Reaction Details Report a problem with these data
Target
Cathepsin L
Ligand
BDBM93181
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±0
Ki
110±0.0 nM
Citation
 Yamashita, DS; Dong, X; Oh, HJ; Brook, CS; Tomaszek, TA; Szewczuk, L; Tew, DG; Veber, DF Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L. J Comb Chem 1:207-15 (1999) [PubMed]  Article 
Target
Name:
Cathepsin L
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
19098.77
Organism:
Homo sapiens (Human)
Description:
Q6LAF7
Residue:
175
Sequence:
VTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESSESDNNKYWLVKN
  
Inhibitor
Name:
BDBM93181
Synonyms:
Cathepsin Inhibitor, Column 5 Row 2
Type:
Small molecule
Emp. Form.:
C36H33N5O4
Mol. Mass.:
599.6783
SMILES:
CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2n1)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1 |r|
Structure:
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