Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase
Ligand
BDBM93321
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
>2.00e+5±n/a nM
Citation
 Choi, SR; Beeler, AB; Pradhan, A; Watkins, EB; Rimoldi, JM; Tekwani, B; Avery, MA Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase. J Comb Chem 9:292-300 (2007) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase
Synonyms:
Lactate dehydrogenase (LDH)
Type:
Protein
Mol. Mass.:
28939.78
Organism:
Plasmodium falciparum
Description:
B9UDZ5
Residue:
267
Sequence:
LIVKKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQ
  
Inhibitor
Name:
BDBM93321
Synonyms:
Oxamic Acid/Ester, 39
Type:
Small molecule
Emp. Form.:
C7H7NO4
Mol. Mass.:
169.1348
SMILES:
OC(=O)C(=O)NCc1ccco1
Structure:
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