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Target
Tyrosine-protein kinase transforming protein Src
Ligand
BDBM3990
Substrate
poly(E,Y)
Meas. Tech.
Kinase Inhibition Assay
IC50
3800±n/a nM
Citation
 Thompson, AM; Fry, DW; Kraker, AJ; Denny, WA Tyrosine kinase inhibitors. 2. Synthesis of 2,2'-dithiobis(1H-indole-3-alkanamides) and investigation of their inhibitory activity against epidermal growth factor receptor and pp60v-src protein tyrosine kinases. J Med Chem 37:598-609 (1994) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase transforming protein Src
Synonyms:
P60-Src | SRC_AVISR | V-SRC | pp60v-src
Type:
Enzyme
Mol. Mass.:
58884.32
Organism:
Avian sarcoma virus
Description:
P00525
Residue:
526
Sequence:
MGSSKSKPKDPSQRRCSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPECPESLHDLMCQCWRRDPEERPTFEYLQAQLLPACVLEVAE
  
Inhibitor
Name:
BDBM3990
Synonyms:
1 H-indole-3-alkanamide deriv. 10a | N-benzyl-2-[2-({3-[(benzylcarbamoyl)methyl]-1H-indol-2-yl}disulfanyl)-1H-indol-3-yl]acetamide
Type:
Small organic molecule
Emp. Form.:
C34H30N4O2S2
Mol. Mass.:
590.758
SMILES:
O=C(Cc1c(SSc2[nH]c3ccccc3c2CC(=O)NCc2ccccc2)[nH]c2ccccc12)NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
poly(E,Y)
Synonyms:
n/a
Type:
Random Polymer
Mol. Mass.:
358.43
Organism:
n/a
Description:
poly[(glu)4(tyr)l]. 5 uM ATP containing 0.2 uCi 32P labeled ATP as co-substrate.
Residue:
3
Sequence:
NA