Reaction Details Report a problem with these data
Target
Cathepsin L2
Ligand
BDBM93434
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
5.5±0
Temperature
300.15±0 K
IC50
>5.0e+4±n/a nM
Citation
 Alvim, J; Severino, RP; Marques, EF; Martinelli, AM; Vieira, PC; Fernandes, JB; da Silva, MF; Corrêa, AG Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors. J Comb Chem 12:687-95 (2010) [PubMed]  Article 
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
  
Inhibitor
Name:
BDBM93434
Synonyms:
Flavonid, 5a
Type:
n/a
Emp. Form.:
C18H18O5
Mol. Mass.:
314.3325
SMILES:
COc1ccc(C(=O)\C=C\c2ccc(OC)cc2OC)c(O)c1
Structure:
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