Reaction Details Report a problem with these data
Target
Cathepsin L2
Ligand
BDBM93445
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
5.5±0
Temperature
300.15±0 K
IC50
1.6e+3± 2e+2 nM
Citation
 Alvim, J; Severino, RP; Marques, EF; Martinelli, AM; Vieira, PC; Fernandes, JB; da Silva, MF; Corrêa, AG Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors. J Comb Chem 12:687-95 (2010) [PubMed]  Article 
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
  
Inhibitor
Name:
BDBM93445
Synonyms:
Flavonid, 6[3,2]
Type:
Small molecule
Emp. Form.:
C17H13FO4
Mol. Mass.:
300.2811
SMILES:
COc1ccc(c(OC)c1)-c1cc(=O)c2cc(F)ccc2o1
Structure:
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