Reaction Details Report a problem with these data
Target
Cathepsin L2
Ligand
BDBM49933
Substrate
n/a
Meas. Tech.
Inhibition Activity Assay
pH
5.5±0
Temperature
300.15±0 K
IC50
1.20e+4± 9e+2 nM
Citation
Alvim, J; Severino, RP; Marques, EF; Martinelli, AM; Vieira, PC; Fernandes, JB; da Silva, MF; Corrêa, AG Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors. J Comb Chem 12:687-95 (2010) [PubMed] Article
More Info.:
Target
Name:
Cathepsin L2
Synonyms:
CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V
Type:
Enzyme
Mol. Mass.:
37341.06
Organism:
Homo sapiens (Human)
Description:
O60911
Residue:
334
Sequence:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
Inhibitor
Name:
BDBM49933
Synonyms:
6-methoxy-2-(4-methoxyphenyl)-1-benzopyran-4-one | 6-methoxy-2-(4-methoxyphenyl)chromen-4-one | 6-methoxy-2-(4-methoxyphenyl)chromone | MLS001049126 | SMR000386953 | cid_688670
Type:
Small organic molecule
Emp. Form.:
C17H14O4
Mol. Mass.:
282.2907
SMILES:
COc1ccc(cc1)-c1cc(=O)c2cc(OC)ccc2o1