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Target
Sentrin-specific protease 8
Ligand
BDBM93620
Substrate
n/a
IC50
434±46 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93620
Synonyms:
6-aminohexyl-(5,6-dimethoxy-8-quinolyl)amine | MLS002638313 | N'-(5,6-dimethoxy-8-quinolinyl)hexane-1,6-diamine | N'-(5,6-dimethoxyquinolin-8-yl)hexane-1,6-diamine | SMR001547800 | cid_224618
Type:
Small organic molecule
Emp. Form.:
C17H25N3O2
Mol. Mass.:
303.3993
SMILES:
COc1cc(NCCCCCCN)c2ncccc2c1OC
Structure:
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