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Target
Sentrin-specific protease 8
Ligand
BDBM93639
Substrate
n/a
IC50
12600±839 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM93639
Synonyms:
1,1-Dimethyl-4-(10-oxo-9,10-dihydro-1-thia-benzo[f]azulen-4-ylidene)-piperidinium | 10-(1,1-dimethyl-4-piperidin-1-iumylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one;iodide | 10-(1,1-dimethylpiperidin-1-ium-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one;iodide | MLS002582473 | SMR000148000 | cid_9551691
Type:
Small organic molecule
Emp. Form.:
C20H22NOS
Mol. Mass.:
324.459
SMILES:
[#6][N+]1([#6])[#6]-[#6]\[#6](-[#6]-[#6]1)=[#6]-1\c2ccsc2-[#6](=O)-[#6]-c2ccccc-12
Structure:
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