Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM34893
Substrate
n/a
IC50
50700±5520 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM34893
Synonyms:
6-N-(benzylideneamino)-2-N,2-N,4-N,4-N-tetramethylpyrimidine-2,4,6-triamine | MLS000709098 | N2,N2,N4,N4-tetramethyl-N6-[(phenylmethylene)amino]pyrimidine-2,4,6-triamine | N2,N2,N4,N4-tetramethyl-N6-[(phenylmethylidene)amino]pyrimidine-2,4,6-triamine | SMR000282965 | [4-(N'-benzalhydrazino)-6-(dimethylamino)pyrimidin-2-yl]-dimethyl-amine | [4-[(N''Z)-N''-benzalhydrazino]-6-(dimethylamino)pyrimidin-2-yl]-dimethyl-amine | [4-[(N'Z)-N'-benzalhydrazino]-6-(dimethylamino)pyrimidin-2-yl]-dimethyl-amine | cid_2853497
Type:
Small organic molecule
Emp. Form.:
C15H20N6
Mol. Mass.:
284.3595
SMILES:
CN(C)c1cc(N=NCc2ccccc2)nc(n1)N(C)C |w:6.5|
Structure:
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