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Target
Caspase-3
Ligand
BDBM93684
Substrate
n/a
IC50
>100000±0 nM
Citation
 PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 in a Caspase-3 Fluorescence assay PubChem Bioassay (2012)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM93684
Synonyms:
1-[(2,6-dimorpholin-4-ylpyrimidin-4-yl)amino]-3-(4-methoxyphenyl)urea | 1-[(2,6-dimorpholinopyrimidin-4-yl)amino]-3-(4-methoxyphenyl)urea | 1-[[2,6-bis(4-morpholinyl)-4-pyrimidinyl]amino]-3-(4-methoxyphenyl)urea | MLS000765810 | SMR000278916 | cid_1109407
Type:
Small organic molecule
Emp. Form.:
C20H27N7O4
Mol. Mass.:
429.4729
SMILES:
COc1ccc(NC(=O)NNc2cc(nc(n2)N2CCOCC2)N2CCOCC2)cc1
Structure:
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