Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM89248
Substrate
n/a
IC50
1090±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89248
Synonyms:
2-(3-Methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-N-(4-trifluoromethyl-benzyl)-acetamide | 2-(3-methyl-4-oxidanylidene-phthalazin-1-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]ethanamide | 2-(3-methyl-4-oxo-1-phthalazinyl)-N-[[4-(trifluoromethyl)phenyl]methyl]acetamide | 2-(3-methyl-4-oxophthalazin-1-yl)-N-[[4-(trifluoromethyl)phenyl]methyl]acetamide | 2-(4-keto-3-methyl-phthalazin-1-yl)-N-[4-(trifluoromethyl)benzyl]acetamide | MLS000523471 | SMR000122544 | cid_1448435
Type:
Small organic molecule
Emp. Form.:
C19H16F3N3O2
Mol. Mass.:
375.3444
SMILES:
Cn1nc(CC(=O)NCc2ccc(cc2)C(F)(F)F)c2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: