Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM89249
Substrate
n/a
IC50
5490±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89249
Synonyms:
(4-Benzothiazol-2-yl-piperazin-1-yl)-[4-(4-fluoro-benzyl)-4H-thieno[3,2-b]pyrrol-5-yl]-methanone | MLS000528994 | SMR000121469 | [4-(1,3-benzothiazol-2-yl)-1-piperazinyl]-[4-[(4-fluorophenyl)methyl]-5-thieno[3,2-b]pyrrolyl]methanone | [4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-[4-[(4-fluorophenyl)methyl]thieno[3,2-b]pyrrol-5-yl]methanone | [4-(1,3-benzothiazol-2-yl)piperazino]-[4-(4-fluorobenzyl)thieno[3,2-b]pyrrol-5-yl]methanone | cid_1427983
Type:
Small organic molecule
Emp. Form.:
C25H21FN4OS2
Mol. Mass.:
476.589
SMILES:
Fc1ccc(Cn2c(cc3sccc23)C(=O)N2CCN(CC2)c2nc3ccccc3s2)cc1
Structure:
Search PDB for entries with ligand similarity: