Reaction Details Report a problem with these data
Target
Protein Wnt-3a
Ligand
BDBM89312
Substrate
n/a
IC50
236±n/a nM
Citation
 PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID] 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM89312
Synonyms:
1-[4-(diethylsulfamoyl)phenyl]sulfonyl-3-piperidinecarboxylic acid ethyl ester | 1-[4-(diethylsulfamoyl)phenyl]sulfonylnipecotic acid ethyl ester | MLS000703709 | SMR000274074 | cid_3188539 | ethyl 1-[4-(diethylsulfamoyl)phenyl]sulfonylpiperidine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H28N2O6S2
Mol. Mass.:
432.555
SMILES:
CCOC(=O)C1CCCN(C1)S(=O)(=O)c1ccc(cc1)S(=O)(=O)N(CC)CC
Structure:
Search PDB for entries with ligand similarity: