Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89721
Substrate
n/a
IC50
941±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89721
Synonyms:
5-[(2-chloranyl-4-fluoranyl-phenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine | 5-[(2-chloro-4-fluorobenzyl)thio]-1,3,4-thiadiazol-2-amine | 5-[(2-chloro-4-fluorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine | 5-[(2-chloro-4-fluorophenyl)methylthio]-1,3,4-thiadiazol-2-amine | MLS000064707 | SMR000077501 | [5-[(2-chloro-4-fluoro-benzyl)thio]-1,3,4-thiadiazol-2-yl]amine | cid_972610
Type:
Small organic molecule
Emp. Form.:
C9H7ClFN3S2
Mol. Mass.:
275.753
SMILES:
Nc1nnc(SCc2ccc(F)cc2Cl)s1
Structure:
Search PDB for entries with ligand similarity: