Reaction Details Report a problem with these data
Target
Xylosyl- and glucuronyltransferase LARGE1
Ligand
BDBM94643
Substrate
n/a
EC50
33300±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule activators of alpha dystroglycan glycosylation PubChem Bioassay (2012)[AID] 
Target
Name:
Xylosyl- and glucuronyltransferase LARGE1
Synonyms:
KIAA0609 | LARG1_HUMAN | LARGE | LARGE1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
88079.63
Organism:
Homo sapiens (Human)
Description:
gi_47678551
Residue:
756
Sequence:
MLGICRGRRKFLAASLSLLCIPAITWIYLFSGSFEDGKPVSLSPLESQAHSPRYTASSQRERESLEVRMREVEEENRALRRQLSLAQGRAPSHRRGNHSKTYSMEEGTGDSENLRAGIVAGNSSECGQQPVVEKCETIHVAIVCAGYNASRDVVTLVKSVLFHRRNPLHFHLIADSIAEQILATLFQTWMVPAVRVDFYNADELKSEVSWIPNKHYSGIYGLMKLVLTKTLPANLERVIVLDTDITFATDIAELWAVFHKFKGQQVLGLVENQSDWYLGNLWKNHRPWPALGRGYNTGVILLLLDKLRKMKWEQMWRLTAERELMGMLSTSLADQDIFNAVIKQNPFLVYQLPCFWNVQLSDHTRSEQCYRDVSDLKVIHWNSPKKLRVKNKHVEFFRNLYLTFLEYDGNLLRRELFGCPSEADVNSENLQKQLSELDEDDLCYEFRRERFTVHRTHLYFLHYEYEPAADSTDVTLVAQLSMDRLQMLEAICKHWEGPISLALYLSDAEAQQFLRYAQGSEVLMSRHNVGYHIVYKEGQFYPVNLLRNVAMKHISTPYMFLSDIDFLPMYGLYEYLRKSVIQLDLANTKKAMIVPAFETLRYRLSFPKSKAELLSMLDMGTLFTFRYHVWTKGHAPTNFAKWRTATTPYRVEWEADFEPYVVVRRDCPEYDRRFVGFGWNKVAHIMELDVQEYEFIVLPNAYMIHMPHAPSFDITKFRSNKQYRICLKTLKEEFQQDMSRRYGFAALKYLTAENNS
  
Inhibitor
Name:
BDBM94643
Synonyms:
1-(3,4-dichlorophenyl)-2-(2-imino-3-prop-2-enyl-1-benzimidazolyl)ethanone;hydrobromide | 1-(3,4-dichlorophenyl)-2-(2-imino-3-prop-2-enylbenzimidazol-1-yl)ethanone;hydrobromide | 2-(2-azanylidene-3-prop-2-enyl-benzimidazol-1-yl)-1-(3,4-dichlorophenyl)ethanone;hydrobromide | 2-(3-allyl-2-imino-benzimidazol-1-yl)-1-(3,4-dichlorophenyl)ethanone;hydrobromide | MLS-0471928.0001 | cid_2881199
Type:
Small organic molecule
Emp. Form.:
C18H15Cl2N3O
Mol. Mass.:
360.237
SMILES:
Clc1ccc(cc1Cl)C(=O)Cn1c2ccccc2n(CC=C)c1=N
Structure:
Search PDB for entries with ligand similarity: