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Target
Sentrin-specific protease 1
Ligand
BDBM94780
Substrate
n/a
IC50
7240±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94780
Synonyms:
2-(4-benzylpiperazin-1-yl)benzo[cd]indole | 2-(4-benzylpiperazino)benzo[cd]indole | 2-[4-(phenylmethyl)-1-piperazinyl]benzo[cd]indole | 2-[4-(phenylmethyl)piperazin-1-yl]benzo[cd]indole | MLS000569410 | SMR000155014 | cid_2325863
Type:
Small organic molecule
Emp. Form.:
C22H21N3
Mol. Mass.:
327.4222
SMILES:
C(N1CCN(CC1)C1=Nc2cccc3cccc1c23)c1ccccc1 |t:8|
Structure:
Search PDB for entries with ligand similarity: